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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1, Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: style="font-size:9.0000pt">Integrative9.0000pt">drug research and developmentof integrative pharmacy and proposes future development strategies for integrative pharmacy.To promote the new drug research and development based on integrative pharmacy, the design idea of integrative,and a new drug development system should be established for integrative drugs.

Keywords： integrative pharmacy integrative drugs new drug development drug evaluation clinical medication guidance

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Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 152-159 doi: 10.1007/s11684-017-0499-6

Abstract: In the meantime, the development of medicine is facing challenges that resulted from the over-divisionconstruct a new medical system that is more suitable for human health and disease treatment, holistic integrativeHIM is the inevitable and necessary direction for the future development of medicine.

Keywords： holistic integrative medicine precision medicine general practice medicine

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3, Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen root system architecture phytohormone crosstalk nitrogen-use efficiency breeding strategy

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Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Strategic Study of CAE 2021, Volume 23, Issue 2, Pages 169-174 doi: 10.15302/J-SSCAE-2021.02.016

Abstract: The Chinese and western integrative medicine, a unique medical model in China, has played an importantWe need to draw experience from the fight against the epidemic to promote the development of Chineseand western integrative medicine and provide intellectual support and theoretical guarantee for the nationalreview and questionnaire survey, and summarize the key roles of this integrative medicine in the preventionSubsequently, we analyze the weaknesses of the integrative medicine in terms of medical resources, clinical

Keywords： Chinese and western integrative medicine evidence-based medicine evaluation system talent training

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The Overall Development Strategy Research of “Internet Plus” Action Plan

Chen Zuoning,Li Bohu,Chai Xudong,Hou Baocun,Liu Yang,Chen Lei and Cheng Lin

Strategic Study of CAE 2018, Volume 20, Issue 2, Pages 1-8 doi: 10.15302/J-SSCAE-2018.02.001

Abstract: justify;">In the phase of new technological revolution and industrial transformation worldwide, the integrativedevelopment of the Internet in technology and industry as well as its application in the economic societyof various fields has a broad development prospect and unlimited potential; this has become the inexorableThis study, beginning from the current development situation, analyzes the problems of “InternetPlus” development in technology and industry as well as its application and cross-border integration

Keywords： Internet Plus integrative development development strategy

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Employing electricity-consumption monitoring systems and integrative time-series analysis models: A case

Seiya MAKI, Shuichi ASHINA, Minoru FUJII, Tsuyoshi FUJITA, Norio YABE, Kenji UCHIDA, Gito GINTING, Rizaldi BOER, Remi CHANDRAN

Frontiers in Energy 2018, Volume 12, Issue 3, Pages 426-439 doi: 10.1007/s11708-018-0560-4

Abstract: set out in global agreements on climate change and low-carbon societies, this paper focuses on the development

Keywords： electricity monitoring electricity demand prediction multiple-variable time-series modeling time-series cluster analysis Indonesia

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Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Article

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Engineering 2020, Volume 6, Issue 11, Pages 1302-1314 doi: 10.1016/j.eng.2020.02.011

Abstract:

Primary hepatocytes (PHCs) are widely used in various fields, but the progressive deterioration of liver-specific features in vitro significantly limits their application. While the transcriptional regulation and whole cell proteome (WCP) of PHCs have been extensively studied, only a small number of studies have addressed the role of posttranslational modifications in this process. To elucidate the underlying mechanisms that induce dedifferentiation, we carried out parallel quantifications of the transcriptome, WCP, ubiquitinome, and phosphoproteome of rat PHCs after 0, 6, 12, 24, and 48 h of in vitro culture. Our data constitute a detailed proteomic analysis of dedifferentiated PHCs including 2196 proteins, 2056 ubiquitinated sites, and 4932 phosphorylated peptides. We revealed a low correlation between the transcriptome and WCP during dedifferentiation. A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiation of PHCs led to an increase in nondegradative K27 ubiquitination. Functional analysis of the altered phosphoproteins suggested a significant enrichment in ferroptosis. In all, 404 proteins with both ubiquitination and phosphorylation were identified to be involved in critical metabolic events. Furthermore, Ptbp1, Hnrpd, Hnrnpu, and Srrm2 were identified as hub genes. Taken together, our data provide new insights into proteome dynamics during PHC dedifferentiation and potential targets to inhibit the dedifferentiation process.

Keywords： Ubiquitination Phosphoproteome Proteome Dedifferentiation Primary hepatocytes

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Innovative development path of ethnomedicines: the interpretation of the path

Zhaoyun Zhu,Dehuan Fu,Yali Gui,Tao Cui,Jingkun Wang,Ting Wang,Zhizhong Yang,Yanfei Niu,Zhennan She,Li Wang

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 32-47 doi: 10.1007/s11684-016-0495-2

Abstract:

One of the primary purposes of the innovative development of ethnomedicines is to use their excellentThe innovative development path of ethnomedicines includes the following three primary stages: resourcestudy, standardized development research, and industrialization of the achievements and efforts forThe implementation of this path is always guaranteed by the research and development platform and thepath of ethnomedicines to provide useful references for the development of proper ethnomedicine use.

Keywords： ethnomedicines innovative development path resource study standardized development research industrialization

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Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 590-594 doi: 10.1007/s11684-017-0537-4

Abstract:

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approachto guideline development for clinical practice.In this study, we review the advantages and limitations of the GRADE approach in the guideline developmentThe limitations of GRADE in the development of guidelines for acupuncture and moxibustion include ratingIn the guideline development for clinical practice with acupuncture and moxibustion, we suggest that

Keywords： guideline acupuncture GRADE

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Lean Product Development—Faster, Better … Cleaner?

Geert Letens

Frontiers of Engineering Management 2015, Volume 2, Issue 1, Pages 52-59 doi: 10.15302/J-FEM-2015007

Abstract: To address this challenge, lean product development has emerged to become the leading improvement methodologyWhile lean product development has its origin in the best practice studies of Japanese car manufacturersThe primary purpose of this work is to untangle the fuzziness that still surrounds lean product developmentand to ground the key aspects of lean product development based on insights from six studies publishedThis demonstrates how better and faster product development can be achieved through the integration of

Keywords： lean product development sustainability engineering responsible design

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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation of AMP-activated protein kinase (AMPK). Meanwhile, many novel targets of metformin have been gradually discovered. In recent years, multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes. Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological disorders. We comprehensively discussed the pharmacokinetic properties and the mechanisms of action, treatment strategies, the clinical application, the potential risk of metformin in various diseases. This review provides a brief summary of the benefits and concerns of metformin, aiming to interest scientists to consider and explore the common and specific mechanisms and guiding for the further research. Although there have been countless studies of metformin, longitudinal research in each field is still much warranted.

Keywords： metformin metabolism cancer aging neurological disorder

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Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

Frontiers in Energy 2007, Volume 1, Issue 2, Pages 125-128 doi: 10.1007/s11708-007-0015-9

Abstract: By analyzing the challenges of China s energy supply, an excellent perspective of nuclear power developmentTaking into account the near-, mid-, and long-term development requirements, a comprehensive, coordinated

Keywords： development excellent perspective long-term development comprehensive national

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SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 1,

Abstract: required to meet to this demand, and (3) the opportunities to integrate broader societal goals into the developmentThere is ample room for development of crop-livestock farms in Africa, and keeping integration as partof the development will help prevent many of the mistakes and environmental problems related to theThis development can integrate biodiversity, climate change adaptation and mitigation to the current

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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 4, Pages 385-396 doi: 10.1007/s11783-008-0073-1

Abstract: Development of more environmentally sustainable wastewater treatment chains in which physical/chemical

Keywords： control beneficial valuable scarcity Development

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 33-41 doi: 10.15302/J-FASE-2018228

Abstract: Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a largeprocess occurring after fertilization and critical roles of epigenetic modifiers during preimplantation developmenttools also presents an alternative approach to the functional annotation of genes critical to early development

Keywords： bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript

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Title Author Date Type Operation

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Journal Article

Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Journal Article

ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Journal Article

Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Journal Article

The Overall Development Strategy Research of “Internet Plus” Action Plan

Chen Zuoning,Li Bohu,Chai Xudong,Hou Baocun,Liu Yang,Chen Lei and Cheng Lin

Journal Article

Employing electricity-consumption monitoring systems and integrative time-series analysis models: A case

Seiya MAKI, Shuichi ASHINA, Minoru FUJII, Tsuyoshi FUJITA, Norio YABE, Kenji UCHIDA, Gito GINTING, Rizaldi BOER, Remi CHANDRAN

Journal Article

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Journal Article

Innovative development path of ethnomedicines: the interpretation of the path

Zhaoyun Zhu,Dehuan Fu,Yali Gui,Tao Cui,Jingkun Wang,Ting Wang,Zhizhong Yang,Yanfei Niu,Zhennan She,Li Wang

Journal Article

Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Journal Article

Lean Product Development—Faster, Better … Cleaner?

Geert Letens

Journal Article

The development and benefits of metformin in various diseases

Journal Article

Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

Journal Article

SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

Journal Article